A collaboration with Claude Opus 4.6 with annonymity and privacy maintained Clincal Evidence Based Parameters and impeded over extrapolation safetyrails
Top Leverage Points
| Trait | Score | Level | Key SNPs |
|---|---|---|---|
| Brain Resilience Reserve | 4/10 | Moderate Reserve | APOE E3/E4, BDNF Val66Met CT, MTHFR 677 CT |
| Marine omega-3 requirement | 8/10 | High | FADS1 GT, IL6 -174 CG, IL1RN TT, CRP AA |
| Baseline inflammatory reactivity | 8/10 | High | CRP AA, IL1RN TT, IL6 CG, IL1A TG/TC |
| Vulnerability to overstimulation and anxiety | 7/10 | High | FKBP5 CT, BDNF CT, HTR1A GG, SLC6A4 AC |
| Need for regular calming / down-regulation practices | 7/10 | High | FKBP5 CT, SLC6A4 AC, BDNF CT, HTR1A GG |
Top Protective Factors
| Trait | Score | Level | Key SNPs |
|---|---|---|---|
| Sensitivity to alcohol (low physiological reactivity) | 3/10 | Low | ALDH2 GG, COMT GG |
| Carbohydrate tolerance (favourable) | 3/10 | Low | TCF7L2 CC, SLC2A2 CC, PPARG CC |
| Iron overload risk | 4/10 | Moderate | HFE C282 CC, HFE H63D HD |
| Dopamine / reward signalling efficiency | 3/10 | Low | DRD2 Taq1A TT, COMT GG, DRD4 |
| Caffeine clearance axis (fast PFC turnover) | — | — | COMT GG (Warrior), CYP1A2 CA |
| Trait | Score | Level | Key SNPs |
|---|---|---|---|
| Sensitivity to mold / biotoxins | 6/10 | Moderate (low confidence) | GSTM1 deletion, GSTP1 AG, SOD2 TC, GPX1 CT |
| Sensitivity to alcohol | 3/10 | Low | ALDH2 GG, CYP1A2 CA, COMT GG |
| Caffeine & stimulant sensitivity | 5/10 | Moderate | CYP1A2 CA, COMT GG |
| Need for 8+ hours of high-quality sleep | 6/10 | Moderate | FKBP5 CT, SLC6A4 AC, BDNF CT, CLOCK TT |
| Need for regular calming / down-regulation practices | 7/10 | High | FKBP5 CT, SLC6A4 AC, BDNF CT, HTR1A GG |
| Trait | Score | Level | Key SNPs |
|---|---|---|---|
| Dietary protein need | 6/10 | Moderate | FTO AA, ACTN3 XX, MTHFR CT |
| Carbohydrate tolerance | 3/10 | Low | TCF7L2 CC, SLC2A2 CC, PPARG CC, FTO AA |
| Marine omega-3 requirement | 8/10 | High | FADS1 GT, IL6 CG, IL1RN TT, CRP AA |
| High-density / refined carbohydrate sensitivity | 5/10 | Moderate | FTO AA, TCF7L2 CC, APOA2 TT, PPARG CC |
| Fat metabolism efficiency | 4/10 | Moderate | APOE E3/E4, LPL CC, CETP GG, APOC3 CC |
| Sodium sensitivity | 4/10 | Moderate | ACE II, AGT TT, eNOS GG |
| Iron overload risk | 4/10 | Moderate | HFE C282 CC, HFE H63D HD |
| Vitamin D synthesis and signalling efficiency | 6/10 | Moderate | VDR FokI TC, GC GT, GC TT, CYP2R1 AA |
| Trait | Score | Level | Key SNPs |
|---|---|---|---|
| Methylation support need | 6/10 | Moderate | MTHFD1 AA, MTHFR 677 CT, MTRR AG |
| Natural detoxification speed | 6/10 | Moderate | GSTM1 deletion, GSTP1 AG, GSTT1 present, CYP1A2 CA |
| Oxidative stress resilience | 4/10 | Moderate | SOD2 TC, GPX1 CT, CAT CT, NRF2 AA |
| Baseline inflammatory reactivity | 8/10 | High | CRP AA, IL1RN TT, IL6 CG, IL1A TG/TC |
| Neuroinflammatory tone | 7/10 | High | IL6 CG, IL1RN TT, APOE ε4, BDNF CT |
| Dopamine / reward signalling efficiency | 3/10 | Low | DRD2 Taq1A TT, COMT GG, DRD3 CT |
| Serotonin regulation resilience | 4/10 | Moderate | SLC6A4 AC, HTR1A GG, BDNF CT, FKBP5 CT |
| Lipid and lipoprotein handling efficiency | 4/10 | Moderate | APOE E3/E4, PON1 GA, LPL CC, APOA5 TC |
| Vascular / blood-flow regulation efficiency | 6/10 | Moderate | eNOS GG, ACE II, AGT TT, VEGF GG |
| Glucose regulation efficiency | 7/10 | High | TCF7L2 CC, SLC2A2 CC, PPARG CC, ADIPOQ AG |
| High-fat diet tolerance and ketone ability | 4/10 | Moderate | APOE E3/E4, APOA2 TT, PPARA GG, FABP2 GA |
| Trait | Score | Level | Key SNPs |
|---|---|---|---|
| Brain Resilience Reserve | 4/10 | Moderate Reserve | APOE E3/E4, BDNF CT, MTHFR CT, SOD2 TC |
| Addiction Risk | 4/10 | Moderate | DRD2 Taq1A TT, OPRM1 AA, GABRA2 CC, COMT GG |
| Mood Disorder Risk | 6/10 | Moderate | BDNF CT, SLC6A4 AC, HTR1A GG, FKBP5 CT |
| Vulnerability to overstimulation and anxiety | 7/10 | High | FKBP5 CT, BDNF CT, HTR1A GG, SLC6A4 AC |
| Perfectionism drive | 4/10 | Moderate | COMT GG, DRD2 TT, BDNF CT, ANK3 |
| PTSD risk and follow-up therapy need | 6/10 | Moderate | FKBP5 CT, BDNF CT, SLC6A4 AC, COMT GG |
| Novelty seeking impulse | 5/10 | Moderate | DRD4, DRD2 TT, COMT GG, AKT1 CC |
| Alcohol dependence risk | 5/10 | Moderate | OPRM1 AA, GABRA2 CC, DRD2 TT, SLC6A4 AC |
| Cannabis dependence risk | 5/10 | Moderate | CNR1 TT, FAAH CC, AKT1 CC, DRD2 TT |
| Nicotine dependence risk | 4/10 | Moderate | CHRNA5 GG, CHRNA3 GG, DRD2 TT, COMT GG |